Protein - Protein Interactions
Proteins are interacting with other proteins. Therefore, it is important to study the interaction partners of the protein for a better understanding of our desired protein. Protein-protein interacting maps show the interacting partners visually. STRING is used for my semester project and it provides a database of known and predicted protein interactions. The interactions include direct (physical) and indirect (functional) associations.
Protein Interactions of BMPR2
BMPR2 Protein Interactions Map
Analysis
STRING is used to see how BMPR2 protein interact with other proteins and String shows that BMPR2 Protein interacts with BMP proteins which are related to Estrogen which I used for my semester project. BMPs (Bone Morphogenetic Protein ) are related with inducing cartilage and bone formation.
References
- Header Image: Positive selection at the protein network periphery: Evaluation in terms of structural constraints and cellular context. (n.d.). Positive selection at the protein network periphery: Evaluation in terms of structural constraints and cellular context. Retrieved May 19, 2014, from http://www.pnas.org/content/104/51/20274/F1.expansion.html
- Stelzl, U., Bock, N., Abraham, C., Mintzlaff, S., Timm, J., Worm, U., et al. (2005). A Human Protein-Protein Interaction Network: A Resource for Annotating the Proteome. Cell, 122(6), 957-968.
- STRING: functional protein association networks. (n.d.). STRING: functional protein association networks. Retrieved May 18, 2014, from http://string-db.org
- STRING: functional protein association networks. (n.d.). STRING: functional protein association networks. Retrieved May 19, 2014, from http://string-db.org/newstring_cgi/show_network_section.