Homology of DNA
Homology of DNA is the study of the identification of evolutionary relationships by comparing similarity in DNA sequence. [1]
Related organisms have similar characteristics derived from common ancestors. [2] Using homology, it is available to study not only evolutionary relationship between different species but also diseases.
Related organisms have similar characteristics derived from common ancestors. [2] Using homology, it is available to study not only evolutionary relationship between different species but also diseases.
Homology of BMPR2 Gene
To find the Homologs of the BMPR2 Gene, NCBI's BLAST (Basic Local Alignment Search Tool) program was used. The BLAST is a good source to start to find homologs. If we input a sequence what we are interesting and let the BLAST run, it provides other species' potential homologous genes based on the percentage of identity of the sequences.
Figure1. Homologues of the BMPR2 gene with percent of nucleotides identical to human
Analysis
By comparing Homologs and how identical the sequences are in reference to the Human BMPR2 gene, as can be seen in Figure 1, BMPR2 is very well conserved. Chimpanzee is the most identical organism to Human and it makes sense since Chimpanzee is the closest evolutionary relatives to Human.
Homolog Reference Pages and Numbers
Chimpanzee (P. troglodytes)
Accession Number: XM_001172748.3 GI Number: 410036066 FASTA E value: 0 Max identical: 99% Cattle (B. taurus)
Accession Number: XM_002685492.2 GI Number: 528939839 FASTA E value: 0 Max identical: 89% |
Mouse (M. musculus)
Accession Number: NM_007561.4 GI Number: 469469045 FASTA E value: 0 Max identical: 91% Chicken (G. gallus)
Accession Number: NM_001001465.1 GI Number: 47825378 FASTA E value: 0 Max identical: 81% |
Gray wolf (C. lupus)
Accession Number: XM_536035.4 GI Number: 545556433 FASTA E value: 0 Max identical: 90% Zebrafish (Dario rerio)
Accession Number: NM_001204.6 GI Number: 189339276 FASTA E value: 0 Max identical: 76% |
References
- Header Image: http://www.mun.ca/biology/scarr/Homology_of_forelimbs.htm
- Identification of Homology in Protein Structure Classification. (n.d.). National Center for Biotechnology Information. Retrieved May 17, 2014, from http://www.ncbi.nlm.nih.gov/pubmed/11685241
- Homologies. (n.d.). Homologies. Retrieved May 17, 2014, from http://evolution.berkeley.edu/evolibrary/article/lines_04