Homology of Protein
Homology of Protein is the study of the identification of evolutionary relationships by comparing similarity in amino acid sequence [1]. Related organisms have similar characteristics derived from common ancestors [2]. Using homology, it is available to study not only evolutionary relationship between different species but also diseases.
Homology of BMPR2 Protein
To find the Homologs of the BMPR2 Protein, NCBI's BLAST (Basic Local Alignment Search Tool) program was used. The BLAST is a good source to start to find homologs. If we input a sequence what we are interesting and let the BLAST run, it provides other species' potential homologous genes based on the percentage of identity of the sequences.
Figure 1. Homologues of the BMPR2 Protein with percent of identical amino acids to human
Analysis
By comparing Homologs and how identical the sequences are in reference to the Human BMPR2 protein, as can be seen in Figure 1, BMPR2 is very well conserved. Chimpanzee is the most identical organism to Human and it makes sense since Chimpanzee is the closest evolutionary relatives to Human. C. elegans is the farthest evolutionary relatives to Human among the compared organisms and it makes sense since C. elegans does not have a heart.
Homolog Reference Pages and Numbers
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Chimpanzee (P. troglodytes)
Accession Number:XP_001172748.1 GI Number: 114582697 FASTA Max identical: 99% Fruit fly
(Drosophila melanogaster) Accession Number:NP_001261395.1 GI Number: 442630098 FASTA Max similar: 37% |
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References
- Header Image: http://www.mun.ca/biology/scarr/Homology_of_forelimbs.htm
- Identification of Homology in Protein Structure Classification. (n.d.). National Center for Biotechnology Information. Retrieved May 17, 2014, from http://www.ncbi.nlm.nih.gov/pubmed/11685241
- Homologies. (n.d.). Homologies. Retrieved May 17, 2014, from http://evolution.berkeley.edu/evolibrary/article/lines_04